Journal
CYTOKINE
Volume 20, Issue 3, Pages 121-129Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/cyto.2002.1989
Keywords
human; IL-15 mutants; IL-2 receptor; mouse; species specificity
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Interleukin (IL-) 2 and IL-15 share the IL-2 receptor betagamma(c) subunits (IL-2Rbetagamma(c)) but have specific, unique a receptor subunits. We studied species specificity of human (hu), simian (si), and mouse (mu) IL-15 and found that hu and A IL-15 behaved similarly in all systems investigated. Hu and mu IL-15 bound hu or mu IL-15Ralpha with equal high affinity in the presence or absence of IL-2Rbetagamma(c), and exhibited similar proliferative activities on cells containing all three subunits. However, quantitative differences were noted in the specific activity of hu and mu IL-15 in both in vitro and in vivo systems utilizing IL-2Rbetagamma(c) in the absence of IL-15Ralpha. These data show that hu IL-15 may be used in mouse model systems, however care must be taken when comparing the efficacy and toxicity of cytokines across species. (C) 2002 Elsevier science Ltd. All rights reserved.
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