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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 124, Issue 45, Pages 13434-13436Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja027538k
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Described is an automated synthesis of hexasaccharicle malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphaticlylincisitol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.
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