Journal
ORGANIC LETTERS
Volume 4, Issue 23, Pages 4005-4008Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol020136x
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[GRAPHICS] alpha-Amino acids are soluble in acetonitrile when treated with phosphazene bases. As a result, the protection/deprotection events that are usually required for peptide coupling reactions can be minimized. This is illustrated in the synthesis of the important angiotensin-converting enzyme (ACE) inhibitor enalapril.
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