Journal
NEURON
Volume 36, Issue 4, Pages 703-712Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(02)01046-2
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Funding
- NEI NIH HHS [R01 EY014127-03, R01 EY007360, R01 EY014127-01A2, EY07360, R01 EY014127-02, R01 EY014127-04, R01 EY014127] Funding Source: Medline
- NICHD NIH HHS [P30 HD018655, P30-HD18655] Funding Source: Medline
- NIGMS NIH HHS [R01 GM037751-13, R01 GM037751-14, R01 GM037751-15, GM18974, R01 GM037751-22, R01 GM037751-20, R01 GM037751-18, R01 GM037751-21, R01 GM018974, R01 GM037751-19, R01 GM037751, R01 GM037751-17, R01 GM037751-16, GM37751, R01 GM037751-23] Funding Source: Medline
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To examine the functions of electrical synapses in the transmission of signals from rod photoreceptors to ganglion cells, we generated connexin36 knockout mice. Reporter expression indicated that connexin36 was present in multiple retinal neurons including rod photoreceptors, cone bipolar cells, and All amacrine cells. Disruption of electrical synapses between adjacent Ails and between Ails and ON cone bipolars was demonstrated by intracellular injection of Neurobiotin. In addition, extracellular recording in the knockout revealed the complete elimination of rod-mediated, on-center responses at the ganglion cell level. These data represent direct proof that electrical synapses are critical for the propagation of rod signals across the mammalian retina, and they demonstrate the existence of multiple rod pathways, each of which is dependent on electrical synapses.
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