Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 136, Issue 2, Pages 359-363Publisher
ELSEVIER
DOI: 10.1016/S0166-4328(02)00130-4
Keywords
dopamine; reward; expectation; placebo effect; nucleus accumbens; Parkinson's disease; positron emission tomography; raclopride
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Using the ability of [C-11]raclopride to compete with dopamine for D-2/D-3 receptors, we investigated by positron emission tomography the effect of placebo (saline) injection on dopamine release in the ventral striatum of patients with Parkinson's disease. We found evidence for placebo-induced dopamine release of similar magnitude to that reported in healthy volunteers after amphetamine administration. However, in contrast to the dorsal striatum, there were no differences in [C-11]raclopride binding potential changes between patients who experienced the reward (those who reported placebo-induced clinical benefit) and those who did not. We conclude that the release of dopamine in the ventral striatum (nucleus accumbens) is related to the expectation of reward and not to the reward itself. These observations have potential implications for the treatment of drug addiction. (C) 2002 Elsevier Science B.V. All rights reserved.
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