Journal
NEUROREPORT
Volume 13, Issue 16, Pages 2059-2063Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200211150-00014
Keywords
ABC transporters; BCRP; blood-brain barrier; brain tumours; endothelium; human; MRP; multidrug resistance; P-gp
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Movement of substrates between blood and brain is known to be influenced by P-glycoprotein (P-gp) at the luminal surface of the endothelium lining brain microvessels and by multidrug resistance associated protein I (MRPI) at the basolateral surface of the choroid plexus epithelium. Here, using RT-PCR and Western blotting, we investigate other ABC transporters in both normal and tumour human brain tissue and demonstrate the presence of breast cancer resistance protein (BCRP). Immunofluorescence confocal microscopy demonstrates that BCRP is located at the blood-brain barrier, mainly at the luminal surface of microvessel endothelium. This localization closely resembles that of P-gp. BCRP has several substrates in common with P-gp and may pose an additional barrier to drug access to the brain.
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