Phosphatidylinositol 3,5-bisphosphate: metabolism and function

Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P-2) is the most recently discovered PtdInsP(2) isomer. It is likely that PtdIns(3,5)P-2 is ubiquitous to eukaryotes, and that it performs a number of important cellular functions, including vacuolar homeostasis, retrograde trafficking from the vacuole, and protein sorting at the multivesicular body. This review describes the metabolism of PtdIns(3,5)P-2 and discusses the potential functions for this lipid. (C) 2002 Elsevier Science (USA). All rights reserved.