Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 407, Issue 2, Pages 143-151Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0003-9861(02)00487-3
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Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P-2) is the most recently discovered PtdInsP(2) isomer. It is likely that PtdIns(3,5)P-2 is ubiquitous to eukaryotes, and that it performs a number of important cellular functions, including vacuolar homeostasis, retrograde trafficking from the vacuole, and protein sorting at the multivesicular body. This review describes the metabolism of PtdIns(3,5)P-2 and discusses the potential functions for this lipid. (C) 2002 Elsevier Science (USA). All rights reserved.
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