Journal
CELL
Volume 111, Issue 4, Pages 589-601Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(02)01078-4
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Funding
- NHLBI NIH HHS [HL65572] Funding Source: Medline
- NIA NIH HHS [AG00259, AG20961, AG09521] Funding Source: Medline
- NICHD NIH HHS [HD18179] Funding Source: Medline
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Adult bone marrow-derived cells (BMDC) are shown to contribute to muscle tissue in a step-wise biological progression. Following irradiation-induced damage, transplanted GFP-labeled BMDC become satellite cells: membrane-ensheathed mononucleate muscle stem cells. Following a subsequent exercise-induced damage, GFP-labeled multinucleate myofibers are detected. Isolated GFP-labeled satellite cells are heritably myogenic. They express three characteristic muscle markers, are karyotypically diploid, and form clones that can fuse into multinucleate cells in culture or into myofibers; after injection into mouse muscles. These results suggest that two temporally distinct injury-related signals first induce BMDC to occupy the muscle stem cell niche and then to help regenerate mature muscle fibers. The stress-induced progression of BMDC to muscle satellite cell to muscle fiber results in a contribution to as many as 3.5% of muscle fibers and is due to developmental plasticity in response to environmental cues.
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