4.6 Article

Proliferation requirements of cytomegalovirus-specific, effector-type human CD8+ T cells

Journal

JOURNAL OF IMMUNOLOGY
Volume 169, Issue 10, Pages 5838-5843

Publisher

AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.169.10.5838

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Two prototypic types of virus-specific CD8(+) T cells can be found in latently infected individuals: CD45R0(+)CD27(+)CCR7(-) effector-memory, and CD45RA(+)CD27(-)CCR7(-) effector-type cells. It has recently been implied that CD45RA+CD27-CCR7- T cells are terminally differentiated effector cells and as such have lost all proliferative capacity. We show in this study, however, that stimulation of CMV-specific CD45RA(+)CD27(-)CCR7(-) T cells with their cognate peptide in concert with either CD4(+) help or IL-2, IL-15, or IL-21 in fact induces massive clonal expansion. Concurrently, these stimulated effector T cells change cell surface phenotype from CD45RA to CD45R0 and regain CCR7, while effector functions are maintained. Our, data imply that CD45RA+CD27-CCR7- effector-type T cells contribute to immunity not only by direct execution of effector functions, but also by yielding progeny in situations of viral reinfection or reactivation.

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