Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 50, Issue 24, Pages 6993-6996Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jf020504b
Keywords
natural repellent; mosquito; Aedes aegypti; Foeniculum vulgare; (+)-fenchone; (E)-9-octadecenoic acid; (Z)-9-octadecenoic acid; deet
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The repellent activity of materials derived from the methanol extract of fruits from Foeniculum vulgare against hungry Aedes aegypti females was examined using skin and patch tests and compared with. that of the commercial N,N-diethyl-m-toluamide (deet) and (Z)-9-octadecenoic acid. The biologically active constituents of the Foeniculum fruits were characterized as (+)-fenchone and (E)-9-octadecenoic acid by spectroscopic analyses. Responses varied according to compound, dose, and exposure time. In a skin test with female mosquitoes, at a dose of 0.4 mg/cm(2), (+)-fenchone and (2)-9-octadecenoic acid exhibited moderate repellent activity at 30 min after treatment, whereas deet provided > 1 h of protection against adult mosquitoes at 0.2 mg/cm(2) (1)-9-Octadecenoic acid was a more potent. repellent agent than (E)-9-octadecenoic acid. (+)-Fenchone and (E)-9-octadecenoic acid merit further study as potential mosquito repellent agents. or as lead compounds.
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