Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 45, Issue 24, Pages 5406-5409Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm011062i
Keywords
-
Categories
Ask authors/readers for more resources
The synthesis and evaluation of activity of some nitric acid esters of substituted morpholines are presented. All compounds inhibit lipid peroxidation and reduce cholesterol (20-63%) and triglyceride (37-85%) plasma levels. The more potent NO donors 14 and 17 specifically reduce low-density lipoprotein (LDL). These data indicate that proper structural modifications to the hypolipidemic and antioxidant morpholines enabling NO production; besides preserving or enhancing the above activities, offer a remarkable reduction of LDL, considered advantageous for antiatheromatic agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available