Journal
NEUROSCIENCE LETTERS
Volume 333, Issue 2, Pages 91-94Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(02)01005-4
Keywords
nicotinamide; ketamine; middle cerebral artery occulusion model; adenosine triphosphate; nicotinamide adenine; DNA fragmentation
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Funding
- NINDS NIH HHS [NS14543, NS25372, NS38653] Funding Source: Medline
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This study examined the effects of nicotinamide on adenosine triphosphate (ATP) and nicotinamide adenine (NAD) levels and poly(adenosine diphosphate-ribose) (poly(ADP-ribose)) polymerase activity following ischemia and reperfusion in ketamine pretreated rats. Nicotinamide was administered at the end of the ischemic period. Nicotinamide protected against the depletion of ATP and NAD at 6 and 24 h of reperfusion. Nicotinamide is known to inhibit poly(ADP-ribose) polymerase at early time points, but was found to increase poly(ADP-ribose) polymerase activity at 24 h of reperfusion. It appears that nicotinamide can help maintain cellular energetics during reperfusion, thereby protecting cells from necrotic and apoptotic mechanisms. (C) 2002 Published by Elsevier Science Ireland Ltd.
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