Stereoselective synthesis of (S)-(+)-lycoperdic acid through an endo selective hydroxylation of the bicyclic lactam enolate with MoOPH

Efficient synthesis of (S)-(+)-lycoperdic acid has been achieved by use of the stereoselective hydroxylation of the enolate derived from the bicyclic lactam 3 with the molybdenum oxidizing reagent, MoOPH (MOO(5)(.)Py(.)HMPA, oxodiperoxymolybdenum(pyridine)(hexamethylpbospboric triamide)), as a key step. (C) 2002 Elsevier Science Ltd. All rights reserved.