Journal
BIOMATERIALS
Volume 23, Issue 24, Pages 4811-4818Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(02)00232-6
Keywords
hydroxyapatite; collagen; cross-linking; glutaraldehyde; FT-IR
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FT-IR analysis was performed for the hydroxyapatite (HAp)/collagen (COL) nanocomposite cross-linked by glutaraldehyde (GA). The amide bands 1, II and III from COL matrix, and phosphate and carbonate bands from HAp were identified. The amide B band arising from C-H stretching mode showed a sensitive conformation by the degree of cross-linking. The amide I band showed a complicate conformational change by the degree of cross-linking. The characteristic amide I band at 1685 cm(-1), which is known as an aging parameter in the biological bone, did not show a monotonous tendency by the degree of cross-linking. The relative contents of the organics in the cross-linked HAp/COL nanocomposite were evaluated as an integration ratio between the amide I band at 1600-1700 cm(-1) and PO43- band at 900-1200 cm(-1). The increase of the organics content by the cross-linking is enabled by the further organization of Ca2+ ions of HAp crystals in HAp/COL nanocomposite. The complicate conformational behavior in the amide I, II and III bands seems to be affected by the cross-linking induced directional arrangement of HAp/COL nanocomposite fibrils. (C) 2002 Elsevier Science Ltd. All rights reserved.
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