Journal
BIOMATERIALS
Volume 23, Issue 23, Pages 4609-4614Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(02)00207-7
Keywords
CM-chitosan; fibroblast; keloid; proliferation; collagen; biomaterial
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In this study, different molecular weight CM-chitosans were prepared and the effects on the growth and collagen secretion of normal skin fibroblasts and keloid fibroblasts were investigated in vitro. CM-chitosan promoted the proliferation of the normal skin fibroblast significantly but inhibited the proliferation of keloid fibroblast. The higher CM-chitosan concentration had a higher initial effect and the lower CM-chitosan concentration had a longer affecting time to the normal skin fibroblast. The lower molecular weight CM-chitosan had significant twofold activities. The CM-chitosan could reduce the ratio of type I/III collagen in keloid fibroblast by inhibiting the secretion of collagen type 1; and had no effect on the secretion of types I and III collagen in the normal skin fibroblast. (C) 2002 Elsevier Science Ltd. All rights reserved.
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