Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 23, Pages 12349-12354Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.23.12349-12354.2002
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Funding
- NIAID NIH HHS [R01 AI045297, R56 AI045297, AI 45297] Funding Source: Medline
- NIGMS NIH HHS [GM51747, GM19789-02, R01 GM051747, F32 GM019789] Funding Source: Medline
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The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in vitro and within cells via direct access to chromatin, resulting in increased LTR expression.
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