Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 133, Issue 1-2, Pages 116-123Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00368-5
Keywords
TWEAK; cytokines; glial cells; experimental auto-immune encephalomyelitis
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TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently identified Fn14 receptor. TWEAK expression was analyzed on mouse microglial cells and astrocytes. Both cell types express TWEAK mRNA. Astrocytes expressed Fn14 and proliferated in the presence of rTWEAK. TWEAK mRNA is expressed in normal CNS and its steady state level increases in spinal cord during EAE. Finally, EAE severity is enhanced in soluble TWEAK-overexpressing transgenic mice. These results support the contention that TWEAK is involved in CNS inflammation. (C) 2002 Elsevier Science B.V. All rights reserved.
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