Journal
OBESITY RESEARCH
Volume 10, Issue 12, Pages 1232-1240Publisher
NORTH AMER ASSOC STUDY OBESITY
DOI: 10.1038/oby.2002.168
Keywords
smoking; dopamine transport; African American
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Funding
- NCI NIH HHS [R01 CA63562] Funding Source: Medline
- PHS HHS [P50 87,418] Funding Source: Medline
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Objective: To assess the association between a polymorphism related to dopamine function, dopamine transport (SLC6A3), and obesity in smokers. Research Methods and Procedures: Logistic regression was used to assess the relationship between this genetic polymorphism and obesity (body mass index greater than or equal to30 kg/m(2)) from a sample of 510 smokers who smoked at least 10 cigarettes per day and who were participating in a study designed to examine genetic and nongenetic predictors of response to a pharmacological treatment. Results: The likelihood of obesity in African Americans (N = 90) with the 10/10 SLC6A3 genotype was 5.16 times that of African Americans with 9/9 or 9/10 SLC6A3 genotypes (odds ratio = 5.16, confidence interval = 1.60 to 16.65). There was no association of the SLC6A3 genotype with obesity for non-Hispanic whites (N = 420). Discussion: These results suggest that variants of the dopamine transporter gene may be related to obesity in African-American smokers. Possible mechanisms responsible for the association between dopamine transport and obesity in African-American smokers are discussed.
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