4.4 Review

Modelling 'evo-devo' with RNA

Journal

BIOESSAYS
Volume 24, Issue 12, Pages 1164-1177

Publisher

WILEY
DOI: 10.1002/bies.10190

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Funding

  1. NIA NIH HHS [R01 AG034994] Funding Source: Medline

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The folding of RNA sequences into secondary structures is a simple yet biophysically grounded model of a genotype-phenotype map. Its computational and mathematical analysis has uncovered a surprisingly rich statistical structure characterized by shape space covering, neutral networks and plastogenetic congruence. I review these concepts and discuss their evolutionary implications. (C) 2002 Wiley Periodicals, Inc.

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