Journal
FASEB JOURNAL
Volume 16, Issue 14, Pages 1874-1878Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.02-0548com
Keywords
immunity; chemokine; lysophospholipid; receptor; G-protein
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Funding
- NHLBI NIH HHS [HL-31809] Funding Source: Medline
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Sphingosine 1-phosphate (S1P) from platelets and macrophages stimulates migration and enhances survival of T cells. Mouse spleen CD4 and CD8 T cells are shown to express predominantly S1P(1) (Edg-1) and S1P(4) (Edg-6) G-protein-coupled receptors with only minimal representation of S1P(2), S1P(3), and S1P(5). At and below plasma concentrations of healthy mammals (1 nM-1 muM), S1P evokes trans-Matrigel chemotaxis of mouse CD4 and CD8 T cells and recruits T cells into subcutaneous air pouches. T cell receptor-mediated activation of CD4 T cells suppresses expression of S1P(1) and S1P(4) receptors and eliminates their chemotactic responses to S1P. The immunoregulator FTY720, a structural homologue of S1P, lacks T cell chemotactic activity and competitively inhibits T cell chemotactic responses to S1P in vitro and in vivo. S1P may be a distinctive contributor to compartmental immunity by attracting naive and memory T cells preferentially over activated effector T cells.
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