Journal
APPLIED RADIATION AND ISOTOPES
Volume 57, Issue 6, Pages 853-856Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0969-8043(02)00225-7
Keywords
O-(2-[F-18]fluoroethyl)-L-tyrosine; FET; nucleophilic F-18-fluorination
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A convenient remotely controlled no-carrier-added synthesis of enantiomerically pure O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) is described. This allows the distribution of the radiotracer to other laboratories according to the satellite concept. The radiochemical yield obtained within 80 min is about 60%. The FET containing HPLC fraction can be used immediately (after adding sodium chloride) for human application. (C) 2002 Elsevier Science Ltd. All rights reserved.
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