Journal
BIOCHEMICAL JOURNAL
Volume 368, Issue -, Pages 433-446Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20021051
Keywords
cell-ensemble model; cell population dynamics; oscillatory dynamics; synchronization
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We investigated a cell-population modelling technique in which the population is constructed from an ensemble of individual cell models. The average value or the number distribution of any intracellular property captured by the individual cell model can be calculated by simulation of a sufficient number of individual cells. The proposed method is applied to a simple model of yeast glycolytic oscillations where synchronization of the cell population is mediated by the action of an excreted metabolite. We show that smooth one-dimensional distributions can be obtained with ensembles comprising 1000 individual cells. Random variations in the state and/or structure of individual cells are shown to produce complex dynamic behaviours which cannot be adequately captured by small ensembles.
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