Journal
PEPTIDES
Volume 23, Issue 12, Pages 2283-2306Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(02)00269-3
Keywords
neuropeptides; food intake; body weight; energy homeostasis; hypothalamus
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Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redundant) controlling system. Starvation as well as overfeeding lead to changes in expression levels of these neuropeptides, which act downstream of leptin, resulting in a physiological response. In this review the role of several anorexigenic and orexigenic (hypothalamic) neuropeptides on food intake and body weight regulation is summarized. (C) 2002 Elsevier Science Inc. All rights reserved.
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