Journal
JOURNAL OF NEUROBIOLOGY
Volume 53, Issue 4, Pages 618-632Publisher
WILEY
DOI: 10.1002/neu.10147
Keywords
orexin; M-H; lateral hypothalamus; acetylcholine
Categories
Funding
- NCI NIH HHS [CA79737] Funding Source: Medline
- NINDS NIH HHS [R01 NS022061-18, R01 NS029071, R01 NS022061, R01 NS022061-19, R01 NS022061-17, R01 NS022061-20, R01 NS022061-21, NS29071, NS22061] Funding Source: Medline
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It is well known, although not well understood, that smoking and eating just do not go together. Smoking is associated with decreased food intake and lower body weight. Nicotine, administered either by smoking or by smokeless routes, is considered the major appetite-suppressing component of tobacco. Perhaps the most renowned example of nicotine's influence on appetite and feeding behavior is the significant weight gain associated with smoking cessation. This article presents an overview of the literature at, or near, the interface of nicotinic receptors and appetite regulation. We first consider some of the possible sites of nicotine's action along the complex network of neural and non-neural regulators of feeding. We then present the hypothesis that the lateral hypothalamus is a particularly important locus of the anorectic effects of nicotine. Finally, we discuss the potential role of endogenous cholinergic systems in motivational feeding, focusing on cholinergic pathways in the lateral hypothalamus. (C) 2002 Wiley Periodicals, Inc.
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