Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 66, Issue 12, Pages 2683-2686Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.66.2683
Keywords
theanine; glutamate receptor; neuroprotection; tea
Ask authors/readers for more resources
In an investigation of the mechanisms of the neuroprotective effects of theanine (gamma-glutamylethylamide) in brain ischemia, inhibition by theanine of the binding of [H-3](RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [H-3]kainate, and [H-3](E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1-H-indole-2- carboxylic acid (MDL 105,519) to glutamate receptors was studied in terms of its possible inhibiting effects on the three receptor subtypes (AMPA, kainate, and NMDA glycine), with rat cortical neurons. Theanine bound the three receptors, but its IC50 of theanine was 80- to 30,000-fold less than that of L-glutamic acid.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available