Journal
BIOTECHNOLOGY LETTERS
Volume 24, Issue 24, Pages 2029-2033Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1021368519336
Keywords
fibronectin; mitogen-activated protein kinase; oligopeptides; osteoblast-like cell
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A synthetic oligopeptide, composed of Arg-Gly-Asp (RGD) and its synergistic Pro-His-Ser-Arg-Asn (PHSRN) motifs and a six glycines (G(6)) linker, promoted human osteoblast-like cell (MG-63) adhesion, spreading and mitogen-activated protein kinase ( MAPK) activity in a similar manner to a positive fibronectin control. This synthetic oligopeptide may therefore be a useful osteo-inductive material.
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