Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 25, Issue 6, Pages 817-819Publisher
PHARMACEUTICAL SOCIETY KOREA
DOI: 10.1007/BF02976997
Keywords
Corydalis incisa; Papaveraceae; acetylcholinesterase inhibitor; corynoline
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In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 muM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.
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