Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 13, Issue 12, Pages 4243-4255Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E02-06-0322
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Funding
- NIDDK NIH HHS [DK-56299, R01 DK056299] Funding Source: Medline
- NIEHS NIH HHS [1-P30-ES-06639, P30 ES006639] Funding Source: Medline
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The molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast, relatively little is known about how the organelle functions as cells age. In this report, we characterize age-related changes in peroxisomes of human cells. We show that aging compromises peroxisomal targeting signal 1 (PTS1) protein import, affecting in particular the critical antioxidant enzyme catalase. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor, Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite hydrogen peroxide, and we present evidence that this increased load of reactive oxygen species may further reduce peroxisomal protein import and exacerbate the effects of aging.
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