Covalently bonded adducts of deoxyribonucleic acid (DNA) oligonucleotides with single-wall carbon nanotubes: Synthesis and hybridization

We have developed a multistep route to the formation of covalently linked adducts of single-wall carbon nanotubes (SWNT) and cleoxyribonucleic acid (DNA) oligonucleotides. X-ray photoelectron spectroscopy was used to characterize the initial chemical modification to form amine-terminated SWNTs, which were then covalently linked to DNA. The resulting DNA-SWNT adducts hybridize selectively with complementary sequences, with only minimal interaction with noncomplementary sequences.