Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 13, Issue 6, Pages 429-439Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6101(02)00029-1
Keywords
IL-15; IL-15R alpha; bystander proliferation; lymphoid homeostasis; immunological memory
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Interleukin (IL)-15 is a member of the common gamma chain family of cytokines, and is closely related to IL-2. While these two cytokines share several important biological functions in vitro, recent mouse models have demonstrated unique roles for these two cytokines in supporting lymphoid homeostasis in vivo. IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis. (C) 2002 Elsevier Science Ltd. All rights reserved.
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