Journal
IMMUNOLOGY
Volume 107, Issue 4, Pages 444-451Publisher
WILEY
DOI: 10.1046/j.1365-2567.2002.01523.x
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Funding
- NHLBI NIH HHS [HL 66308, HL48914, HL56416, R01 HL056416, R01 HL066308] Funding Source: Medline
- NIDDK NIH HHS [DK53674, R01 DK053674] Funding Source: Medline
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The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Hex in T cells (CD11a/Hex and Lck/Hex). Both these types of transgenic mouse had the same defects in T-cell maturation, indicating that proper T-cell development may be dependent not just on the up-regulation of lymphoid-specific transcriptional regulators but also on the co-ordinated down-regulation of myeloid-specific transcriptional regulators such as Hex. In addition, Hex over-expression significantly increased myeloid progenitor cycling, which may explain its role in retrovirally induced murine leukaemia.
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