Journal
BRITISH JOURNAL OF DERMATOLOGY
Volume 147, Issue 6, Pages 1237-1240Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2133.2002.04998.x
Keywords
capillary electrophoresis; prolidase; red blood cells
Categories
Ask authors/readers for more resources
Background Prolidase deficiency is a rare genetic disorder for which a cure has not yet been found. Objectives To assess the effectiveness of apheresis exchange as a new therapeutic approach. Methods Apheresis exchanges were repeated monthly for four consecutive months, in parallel, on two patients, replacing prolidase-deficient red blood cells with normal filtered cells. Prolidase activity and urinary dipeptides were determined at regular intervals. Results The constant presence of active prolidase inside cells allowed a continuous, although partial, degradation of imidodipeptides, with a concomitant improvement of skin ulceration. Conclusions Apheresis exchange could be a reasonable way of obtaining a clinical improvement in these patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available