Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 47, Issue 6, Pages 834-840Publisher
MOSBY-ELSEVIER
DOI: 10.1067/mjd.2002.124070
Keywords
-
Categories
Ask authors/readers for more resources
Background: Optimum dosing for botulinum toxin type A (BTX-A) in crow's feet remains to be defined. Objective: Our purpose was to compare the efficacy and safety of 3 doses of BTX-A and placebo in patients with crow's feet. Methods: Patients were treated with 6, 12, or 18 units of BTX-A in orbicularis oculi muscle on one side and placebo contralaterally (double-blind design). At 16 weeks after injection, patients were treated with 12 or 18 units of BTX-A bilaterally (open-label design). Trained observers and patients rated the wrinkles on a scale of 0 (none) to 3 (severe) at maximum contraction and repose and at baseline and 4-week intervals over a 16-week period after injection. Results: All doses of BTX-A were significantly superior to placebo with no clear dose-response relationship. Benefits of the second injection lasted longer than the first. Few and mild adverse events were seen. Conclusion: BTX-A is a safe and effective treatment for crow's feet. Benefits are more sustained with repeat treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available