Journal
SEMINARS IN IMMUNOLOGY
Volume 14, Issue 6, Pages 415-422Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S1044532302000763
Keywords
B lymphopoiesis; BSAP; EBF; lineage commitment; Pax-5
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Funding
- NIAID NIH HHS [P01 AI22295, R01 AI37574, AI 07405] Funding Source: Medline
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B lymphocyte development is regulated by the nuclear proteins Early B cell factor (EBF) and Pax-5. EBF and Pax-5 work separately and in concert to activate genes required for B cell differentiation. Recent studies have defined mechanisms by which these two factors control transcription, including chromatin remodeling activities and recruitment of Partner proteins. This review addresses the structures, functions, and roles of these proteins in early B cell commitment and development, as well as in later stages of B cell differentiation.
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