Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 23, Pages 12344-12348Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.23.12344-12348.2002
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Funding
- NIAID NIH HHS [2 P30 AI 36214, R21 AI047745, R01 AI047745, AI47745, R56 AI047745, P30 AI036214] Funding Source: Medline
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We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.
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