Thermodynamics of partitioning of some sulfonamides in 1-octanol-buffer and liposome systems

The thermodynamics of partitioning of some structurally related sulfonamides have been determined in 1-octanol-aqueous buffer and liposome systems. The partition coefficients were approximately tenfold higher in liposomes compared with I-octanol. The enthalpies of transfer from aqueous media to organic systems were positive in liposomes but negative or positive in 1-octanol, whereas the entropies of transfer were positive in almost all cases. Copyright (C) 2002 John Wiley Sons, Ltd.