Journal
JOURNAL OF LIPID RESEARCH
Volume 43, Issue 12, Pages 1997-2006Publisher
ELSEVIER
DOI: 10.1194/jlr.R200015-JLR200
Keywords
triglycerides; chylomicronemia; atherosclerosis; lipoproteins; lipid metabolism; mutations; human; promoter; review
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Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake. 3) LPL gene regulation: the LPL promoter and its regulatory elements are described.
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