Journal
JOURNAL OF CARDIAC FAILURE
Volume 8, Issue 6, Pages 399-406Publisher
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1054/jcaf.2002.129656
Keywords
autonomic nervous system; sympathetic nerve activity; cardiomyopathy; traditional Chinese medicine
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Funding
- NCCIH NIH HHS [R21AT00671] Funding Source: Medline
- NCRR NIH HHS [5 M01 RR00865-25] Funding Source: Medline
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Background: In heart failure (HF) patients, muscle sympathetic nerve activity is increased. and HF patients with the greatest sympathetic activation have the poorest prognosis. In animals. acupuncture is sympathoinhibitory, and the most profound sympathoinhibition occurs in animals with the highest resting sympathetic nerve activity. The purpose of this study was to test the hypothesis that acupuncture is sympathoinhibitory in humans with HE Methods and Results: Fifteen advanced HF patients underwent acute mental stress testing before and during (1) real acupuncture (n = 10), (2) non-acupoint acupuncture (n = 10). and (3) no-needle acupuncture control (n =10). Muscle sympathetic nerve activity (MSNA) was recorded using peroneal microneurography. Resting MSNA was not different before and after acupuncture (52 +/- 22 versus 50 +/- 21 bursts/min. P = NS). During mental stress, SNA increased significantly. This increase was eliminated following real acupuncture (mean delta MSNA pre-acupuncture versus post-acupuncture: 149 +/- 171 versus - 169 +/- 130. P = .03). but not after non-acupoint or no-needle acupuncture controls. The changes in blood pressure and heart rate during mental stress were not attenuated by real or control acupuncture. Conclusion: Acute acupuncture attenuates sympathoexcitation during mental stress in advanced HF patients.
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