4.5 Article

Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir

Journal

BONE MARROW TRANSPLANTATION
Volume 30, Issue 12, Pages 963-966

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bmt.1703704

Keywords

progressive multifocal leukoencephalopathy; stem cell transplantation; cidofovir

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We report a patient with progressive multifocal leukoencephalopathy (PML) after autologous stem cell transplantation (SCT) for non-Hodgkin's lymphoma (NHL). This is an unusual association, and to date only seven cases have been reported. This is the first case of PML after SCT treated with cidofovir, and the fifth case treated with this drug in a patient without human immunodeficiency virus (HIV) infection. In the previous four patients treated with cidofovir the outcome was discouraging, as was the case in this patient.

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