Journal
TRENDS IN CELL BIOLOGY
Volume 12, Issue 12, Pages 551-555Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(02)02410-8
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- NIGMS NIH HHS [GM-60992, GM-14642] Funding Source: Medline
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Intraflagellar transport involves the movement of large protein particles along ciliary microtubules and is required forth e assembly and maintenance of eukaryotic cilia and flagella. Intraflagellar-transport defects in the mouse cause a range of diseases including polycystic kidney disease, retinal degeneration and the laterality abnormality situs inversus, highlighting the important role that motile, sensory and primary cilia play in vertebrates.
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