Journal
CELL STRUCTURE AND FUNCTION
Volume 27, Issue 6, Pages 403-408Publisher
JAPAN SOC CELL BIOLOGY
DOI: 10.1247/csf.27.403
Keywords
endocytosis; Hrs; multivesicular body; ubiquitin; vacuolar protein sorting
Categories
Ask authors/readers for more resources
Endocytosed receptors are either recycled to the plasma membrane or trapped within intralumenal vesicles of multi-vesicular bodies for subsequent degradation in lysosomes. How the cell is able to sort receptors in endosomes has so far been largely unknown. The hepatocyte growth factor regulated tyrosine kinase substrate, Hrs, is an essential protein that has been implicated in cell signalling and intracellular membrane trafficking. Very recently, several reports have demonstrated a role for Hrs in endocytic sorting of ubiquitinated membrane proteins. Here, we review current knowledge about how Hrs recognises ubiquitinated cargo that is destined for lysosomal degradation, and how Hrs may act as a key regulator of the molecular machinery involved in receptor sorting and multivesicular body formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available