Journal
MODERN PATHOLOGY
Volume 15, Issue 12, Pages 1357-1365Publisher
NATURE PUBLISHING GROUP
DOI: 10.1097/01.MP.0000039572.75188.1A
Keywords
catenins; E-cadherin; immunohistochemistry; invasion; p120; prolactinoma; proliferation
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E-cadherin/catenin complex regulates cellular adhesion and motility and is believed to function as an invasion suppressor system. In a number of cancers, abnormal and reduced expression of E-cadherin/catenin complex is associated with tumor invasion and metastasis. Prolactinomas show frequent invasion on the surrounding structures, despite their histologically benign nature. Furthermore, gender-based differences in endocrine and surgical findings are found in patients with prolactinoma. To understand biological factors governing prolactinoma behavior, this study analyzed the expression of E-cadherin; alpha-, beta-, and gamma-catenins; p120; and cell proliferation marker MIB-1 labelling index in 13 invasive tumors (9 in men, 4 in women), 26 noninvasive tumors (4 in men, 22 in women), and 8 normal anterior pituitaries by immunohistochemistry. Immunostaining of E-cadherin; alpha-, beta-, and gamma-catenins; and p120 showed a membranous pattern of reactivity and generally stronger in normal pituitaries than in prolactinomas. Expression of E-cadherin and beta-catenin was significantly lower in invasive than in noninvasive prolactinomas (P < .002 and P < .005, respectively), and reduced expression of E-cadherin and beta-catenin was more frequent in invasive than in noninvasive prolactinomas (P < .001 and P < .05, respectively); in contrast, gamma-catenin expression showed higher in invasive than in noninvasive prolactinomas (P < .05). Expression of E-cadherin was significantly lower in macroprolactinomas than in microprolactinomas (P < .01), and decreased expression of E-cadherin and beta-catenin predicted high MIB-1 expression (P < .05). Moreover, the expression of E-cadherin and beta-catenin was significantly lower in macroprolactinomas in men than in those in women (P < .01 and P < .02, respectively). No statistical correlations were observed between expression of a-catenin, p120, and clinicopathologic features. In conclusion, the reduction of E-cadherin and beta-catenin expression was related to invasiveness and proliferative status of prolactinomas and correlated with the more aggressive behavior of prolactinomas in men compared with in women.
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