Journal
CELL STRUCTURE AND FUNCTION
Volume 27, Issue 6, Pages 443-456Publisher
JAPAN SOC CELL BIOLOGY
DOI: 10.1247/csf.27.443
Keywords
MHC class II compartments; exosomes; melanosomes; lysosomes; multivesicular bodies
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Funding
- NEI NIH HHS [R01 EY 12207] Funding Source: Medline
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Lysosomes are ubiquitous organelles that carry out essential household functions. Certain cell types, however, contain lysosome-related organelles with specialized functions. Their specialized functions are usually reflected by specific morphological and compositional features. A number of diseases that develop due to genetic mutations, pathogen exposure or cell transformation are characterized by dysfunctional lysosomes and/or lysosome-related organelles. In this review we highlight adaptations and malfunction of the endosomal/lysosomal system in normal and pathological situations with special focus on MHC class 11 compartments in antigen presenting cells and melanosomes in pigment cells.
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