Journal
INFECTION AND IMMUNITY
Volume 70, Issue 12, Pages 7136-7139Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.70.12.7136-7139.2002
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Funding
- NIAID NIH HHS [R21 AI053517] Funding Source: Medline
- NIDA NIH HHS [R56 DA005084, DA05084, R01 DA005084, DA00204] Funding Source: Medline
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The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-D-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-D-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha.
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