Hydrothermal synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial evaluation of the copper (II) ciprofloxacin complex:: [Cu(cf)2(BF4)2]•6H2O

The hydrothermal reaction of ciprofloxacin (1) with Cu(BF4)(2) . 6H(2)O yields a copper complex having a molecular formula, [CU(cf)(2)(BF4)(2)] . 6H(2)O (cf = ciprofloxacin), which is characterized by spectroscopic and electrochemical measurements as well as single crystal X-ray studies [a = 9.1079(13), b = 9.6112(16), c = 11.4542(18) Angstrom, alpha = 90.518 (19)degrees, beta = 99.160 (18)degrees, gamma = 93.315 (19)degrees, P1 bar, Z = 1]. The F2O4 donor atom set forms a (4 + 2) distorted octahedral geometry around the central copper atom; which has a highly facile copper redox couple (+0.23 V). The copper conjugate exhibits a significant enhancement in the antitubercular activity probably arising out of its rapid intracellular reduction leading to oxygen activation, which is detrimental to the mycobacteria. (C) 2002 Elsevier Science B.V. All rights reserved.