Journal
DIABETES
Volume 51, Issue -, Pages S358-S362Publisher
AMER DIABETES ASSOC
DOI: 10.2337/diabetes.51.2007.S358
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Type 2 diabetes is generally perceived as a polygenic disorder, with disease development being influenced by both hereditary and environmental factors. However, despite intensive investigations, little progress has been made in identifying the genes that impart susceptibility to the common late-onset forms of the disease. E23K, a common single nucleotide polymorphism. in K(IR)6.2, the pore-forming subunit of pancreatic beta-cell ATP-sensitive K+ (K-ATP) channels, significantly enhances the spontaneous open probability. of these channels, and thus modulates sensitivities toward inhibitory and activatory adenine nucleotides. Based on previous association studies, we present evidence that with an estimated attributable proportion of 15% in Caucasians, E23K in K(IR)6.2 appears to be the most important genetic risk factor for type 2 diabetes yet identified.
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