Journal
JOURNAL OF VIROLOGY
Volume 76, Issue 24, Pages 13077-13082Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.76.24.13077-13082.2002
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Funding
- NIAID NIH HHS [R01 AI036554, AI 36554, AI 36059, R37 AI036059] Funding Source: Medline
- PHS HHS [T32 DF 0796] Funding Source: Medline
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Latent human immunodeficiency virus type 1 (HIV-1) persists even in patients treated with antiretroviral therapy. New treatment strategies are therefore needed to eradicate this latent viral reservoir without reducing immune cell function. We characterize the interieukin-7 (IL-7)-induced stimulation of primary human T cells and thymocytes and demonstrate, using the SCID-hu model, that IL-7 induces substantial expression of latent HIV while having minimal effects on the cell phenotype. Thus, IL-7 is a viable candidate to activate expression of latent HIV and may facilitate immune clearance of latently infected cells.
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