Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei

Six new polyketides, bitungolides A-F (1-6), have been isolated from the Indonesian sponge Theonella cf swinhoei and their structures elucidated by spectroscopic data and X-ray diffraction analysis. The bitungolides are a new class of Theonella metabolites that inhibit dual-specificity phosphatase VHR.