Studies of biologically potent organotin(IV) and orgranosilicon(IV) complexes of a sulfur donor ligand derived from 1-acetylferrocene

The coordination and organometallic chemistry of metal-nitrogen- and metal-sulfur-bonded compounds have come to occupy a prominent position in research due to their economical importance in the field of agricultural, medicinal and industrial chemistry. Although Schiff bases of ferrocene derivatives and their metal complexes with lanthanide and transition metal ions have been synthesized and some of their structures characterized, their interaction with main group metal ions and the formation of their coordination complexes are subjects of current interest. This communication deals with a description of synthetic procedure and structural characterization on the basis of analytical and spectroscopic techniques of a new class of coordination compounds of organotin(IV) and organosilicon(IV) with a sulfur-containing ligand moiety derived by the condensation of 1-acetylferrocene and thiosemicarbazide. Finally, attempts have been made to establish a correlation between a variety of biointeraction activities, including antimicrobial activity and antifertility activity, on male rats and the structures of the resulting products on the basis of different constituents and chemical phenomena. Copyright (C) 2002 John Wiley Sons, Ltd.