Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 16, Issue 6, Pages 675-684Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0889-1591(02)00019-3
Keywords
aggression; hostility; anger; tumor necrosis factor-alpha; blood monocytes; atherosclerosis
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Funding
- NHLBI NIH HHS [HL56105] Funding Source: Medline
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Aggression, hostility, and anger significantly predict morbidity and mortality from atherosclerotic cardiovascular disease (ACVD). ACVD is believed to be an inflammatory disease characterized by increased expression of a number of proinflammatory cytokines, such as tumor necrosis factor (TNF)-alpha. This study examined the relation of aggression, hostility, and anger to monocyte-associated TNF-alpha expression following lipopolysaccharide (LPS) stimulation. Participants were 62 healthy, non-smoking men (aged 18-45 years). Hostility, anger, verbal, and physical aggression were assessed using the Buss-Perry aggression questionnaire (BPAQ). LPS-stimulated TNF-alpha expression was determined using dual-color flow cytometry gating for CD14(+) cells. After controlling for age. race, education. and alcohol use, scores on the hostility (p = .013), physical aggression (p = .010). and verbal aggression (p = .034) subscales, and the total score (p = .007) on the BPAQ were positively associated with LPS-stimulated TNF-alpha expression. The results suggest that hostility and aggression are associated with an increased expression of TNF-alpha, a cytokine implicated in ACVD. (C) 2002 Elsevier Science (USA). All rights reserved.
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